Arizona Biological Research Institute

4745 North 7^th Street, Suite 425

Phoenix, Arizona 85014

22 February, 2002

Dear                          ,

The Arizona Biological Research Institute and Foundation is dedicated to developing a unique approach to comprehensive biological health care. Through our vision, the Institute will A) support research in the areas of immune enhancement, degenerative diseases and cardiovascular disorders; B) produce and provide biological products from this and other research to enhance human health; and C.) To establish a clinical environment that serves as a place of regeneration and inspiration, where people are provided with the tools and direction to undergo the transformative process that is required for all true healing.

Dr. Tsuneo Kobayashi, and oncologist in Saitama, Japan has developed a panel of eleven tumor markers coupled with a computerized algorithm that is useful in the early detection of cancer.

The tumor markers are categorized into three types:

                        I) Tumor Specific Markers

                        II) Tumor Associated Tumor Markers

                        III) Growth Related Tumor Markers

Our initial phase will be to learn and replicate his laboratory techniques in Japan, then apply them in the United States through his interaction by split sample assays. Once he is comfortable with our accuracy, he is willing to share his algorithm so that we may establish epidemiological applications within the United States.

Our secondary phase will consist of applying some of his methods in deterring cancer formation at a clinically diagnosed level as well as utilizing other natural methods known in the field of biological medicine that include, but are not limited to hyperthermia, mistletoe therapy, fasting, detoxification, nutritional and botanical therapy.

We will propose this through grant applications from our nonprofit organization, the Arizona Biologic Research Institute.

Respectively,

Frank W. George, DO, MD(H)

Medical Director, AZBRI