marker characteristic to this breast cancer patient, increased gradually after commencement of fasting therapy, and 2 weeks after termination of fasting therapy had returned to its previous level (Fig. 4). Similarly, the ferritin to serum iron ratio (FT/ Fe) increased after commencement of fasting therapy and decreased after its termination. Probably these cancer antigens were released because of the fasting therapy.

4. Effects of Fasting Therapy in Early Cancer Patients. (Fig. 5)
     Figure 5 shows the measurements of the immune parameters in the blood of a 50-year-old male patient with supramandibular carcinoma who carried out one week of fasting therapy. In such case of early cancer, fasting therapy alone produces a comparatively good improvement in immune activity, and can be maintained for several months.

5. Effects of Adoptive Immune (Sensitized Lymphocyte) Therapy (Fig. 6).
     Patients with progressive and advanced cancer (shown in Table 1) were treated with only adoptive immune (sensitized lymphocyte) therapy (Fig. 7), according to schedule 1. The improvement rates for the T -cell number, stimulation index (SI), and NK cytotoxicity were 59% (10/17), 35% (5/14), and 53% (9/17), respectively. These are lower rates of improvement than those for early cancer patients previously reported.¹¹

6. Effects of Combined Fasting Therapy and Adoptive Immune (Sensitized Lymphocyte Therapy (Fig. 8).
     Combined fasting therapy and adoptive immune (sensitized lymphocyte) therapy were carried out according to schedule 2 (Fig. 7). These therapies were carried out on the subjects, the 17 patents in Table 1, for a total of 32 times. The rates of improvement in the immune parameters, T-cell number, SI, and NK cytotoxity increased 70% (22/32), 56% 18/ 32), and 70% (14/20), respectively. The improvement in immune activity by the combined therapies was significantly greater than that of the adoptive immune (sensitized lymphocyte) therapy alone.

We obtained improvement by fasting therapy in early cancer patients in Ryodoraku charts, immune activity, and slightly abnormal levels of serum cyclic nucleotides. Furhermore, the former two improvements were obtained using adoptive immune (sensitized lymphocyte) therapy alone.

In advanced or progressive cancer patients, when fasting therapy was carried out alone, only a slight improvement in immune activity was obtained (unpublished data). Also when adoptive immune (sensitized lymphocyte) therapy was carried out alone, only a small improvement was realized. However, when combined fasting therapy and adoptive immune (sensitized lymphocyte) therapy were carried out, enhancement of immunity of greater significance than their individual application was obtained Generally in the fasting therapy, because there is no way to supplement calories, there is a transient decrease in cellular immune activity due to nutritional insufficiency (unpublished data). In spite of these facts, even in advanced or progressive cancer patients improvement in immune activity was obtained indicating that improvement in abnormal levels of serum cyclic nucleotides is an important factor in immunological enhancement. The serum level of cyclic nucleotides in most patients was normalized after the adoptive immune (sensitized lymphocyte) therapy (unpublished data).

We did not directly sensitize in vitro the lymphocytes used in the adoptive immune (sensitized lymphocytes) therapy but when the cancer antigens are released into the blood by fasting therapy or combined treatment with vitamin A and hyperthermia, the lymphocytes of the healthy donors were infused and sensitized in cancer patients in vivo. Therefore, we designated this method in vivo sensitized lymphocyte therapy.

What we have described above suggests that cyclic nucleotides are the key to psychoneuroimmunomodulators, and that in connection with the CNS, where the center of the autonomic nervous system is located, bioregulation of the immune activity is performed by