cyclic nucleotides. Thus, we may suppose that the biochemical basis of abnormalities in the immunosurveillance system resides in abnormalities of the regulation of cyclic nucleotides. Incidently, we administered dibutyryl cyclic AMP to cancer patients with low serum cyclic AMP level. After the concentration of serum cyclic AMP had increased, we attempted to carry out adoptive immune (sensitized lymphocyte) therapy. However, we did not obtain improvements in immunity (unpublished data), indicating that the immunological enhancement of the fasting therapy is not simply due to elevation in low serum cyclic AMP concentrations.

We suggest first that in the bioregulation of the immune activity, in relation to the CNS, there is participation of serum cyclic nucleotides and, in addition, the role of the immunosurveillance system within the immunological field is regulated by the cyclic nucleotides. Second, the cyclic nucleotides bioregulate lymphocyte development by influencing the thymic hormones and related substances. Furthermore, the mutual relationship between immunological cells is regulated by cyclic nucleotides, which occur in high concentrations in lymphocytes, and cytokines such as monokines and lymphokines.

In sum, it appears that a defective immunosurveillance system is normalized by fasting therapy in the cancer patient. From the above facts, fasting therapy, which exercises great influence on the mind, produced a normalization of serum cyclic nucleotides and enhancement of the immunosurveillance system.

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