Anti-Inflammatory Treatment Benefits Brain Pathology

Since there is no longer any question about the benefit of anti-inflammatory treatment in the prevention of Alzheimer's and Parkinson's disease, please be aware that you can clearly prove anti-inflammatory action with safe natural products that can be taken for a life time, including Wobenzym, FYI. The combination of ingredients including EDTA as found in Essential Daily Defense also inhibits beta amyloid production and can be shown to lower the toxic METALS that contribute to INFLAMMATION in the brain but is also probably the STRONGEST anti-oxidant known.

Garry F. Gordon, MD,DO,MD(H)

www.the-scientist.com
November 14, 2003

NSAIDs alleviate brain pathology

Nonsteroidal antiinflammatory drugs can have beneficial effects on brain pathology | By Tudor Toma

Neuroinflammation and microglial pathology contribute to the severity of many brain disorders, including Alzheimer disease (AD) and Parkinson disease. Chronic inflammation also accompanies brain radiation injury, but the therapeutic roles for nonsteroidal antiinflammatory drugs (NSAIDs) and their mechanisms of action in the brain have been unclear. Two papers in the November 13 Science and Sciencexpress show that NSAIDs can have beneficial effects following cranial radiation therapy and can reduce amyloid formation in AD.

In the first paper, Michelle L. Monje and colleagues at Stanford University used a murine irradiation model. They observed that inflammatory blockade with indomethacin-a common NSAID-restored adult hippocampal neurogenesis following endotoxin-induced inflammation and augmented neurogenesis following cranial irradiation (Sciencexpress, DOI:10.1126/science.1088417, November 13, 2003).

"Our findings may shed some light on the potential contribution of inflammation-induced neurogenic blockade to memory pathology and on the mechanism of the beneficial effects of NSAID treatment in certain dementias," they conclude.

In the second study, Yan Zhou and colleagues from Eli Lilly and Company studied the effect of NSAIDs on a transgenic mouse model of AD. They observed that the Rho-Rock pathway may regulate amyloid precursor protein (APP) processing, and Y-27632, a selective NSAID Rock inhibitor, can reduce Aâ42 through inhibition of Rho activity (Science, 302:1215-1217, November 13, 2003).

"The observed role of Rho-Rock signaling in regulating APP processing and the amount of Aâ42 may provide further insight into the pathogenesis of AD as well as potential new drug targets," suggest Zhou et al.

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