39.

Bradley JE, Powell AM Jr. Oral calcium EDTA in lead intoxication of children. J Ped. 1954; 45:297-301 (Sept.). (2882) [EDTA is an organic chelating agent valuable in treating Pb poisoning. It is most active when administered iv. In the cases here reported it was given to children orally. Five were selected with Pb poisoning contracted from eating paint or plaster containing Pb. In the hospital Pb excreted in their urine was determined by the dithizone method for several days before the EDTA was given at 75 mg/kg weight/day in divided doses at 6-hr intervals. A significant increase in urinary Pb promptly occurred in all the patients. The maximum excretion was reached between the 2nd and 4th days; then the amount excreted dropped, but it remained in excess of normal as long as EDTA was being given. EDTA was well tolerated and brought about disappearance of anorexia and irritability. A number of observations were made during the period on urinary coproporphyrin and on serum Ca and P. The conclusion is that EDTA should be useful in acute Pb intoxication and in Pb encephalopathy, when the rapid elimination of Pb is required. More research is wanted as to iv administration and as to dosage. The value of EDTA is undoubted.

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