111.

Madsen JL, Scharff O, Rabol A, Krogsgaard OW. Relationship between small-intestinal transit rate and intestinal absorption of 14C-labelled mannitol and 51Cr-labelled ethylenediamine-tetraacetic acid in healthy subjects. Scand. J Gastro. 1996; 31(3):254-259. (NA66) Ten healthy men ingested a test solution containing 99mTc-labelled diethylenetriaminepentaacetic acid (99mTc-DTPA), 14C-labelled mannitol (14C-mannitol) and 51Cr-labelled ethylenediaminetetraacetic acid (51Cr-EDTA). After ingestion, the small-intestinal transit rate of 99mTc-DTPA was measured with the gamma camera technique. Urine was collected at 0-2, 2-4 and 4-6 h to measure the excretion of absorbed 14C-mannitol and 51Cr-EDTA. Moreover, the distribution volume and plasma clearance of 14C-mannitol and 51Cr-EDTA were estimated in each subject. A positive correlation was found between mean small-intestinal transit time and 0- to 6-h urinary excretion of 14C-mannitol. No correlation was shown between small-intestinal transit rate and 0- to 6-h urinary excretion of 51Cr-EDTA. Urinary excretion of neither 14C-mannitol nor 51Cr-EDTA was affected by distribution volume or urine volume. A positive correlation was observed between plasma clearance and 0- to 6-h urinary excretion of 14C-mannitol, whereas plasma clearance did not influence urinary excretion of 51Cr-EDTA. Small-intestinal transit rate seems to have a significant effect on 0- to 6-h urinary excretion of 14C-mannitol, whereas small-intestinal transit rate does not influence the timed urinary excretion of 51Cr-EDTA.

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