143.

Batskor IA, Kovacs I, Pasceri I. The effectiveness of CaEDTA-treatment in the prophylaxis of lead intoxication. Zentralblatt fur Arbeitsmedizin Arbeitsschutz. 1961; 11:261-264 (Nov.) (2229) [The prophylactic effect of Mosatil on Pb intoxication was tested on 25 workers in 2 accumulator factories, who did not show clinical signs of Pb intoxication (Pb-line, pallor, etc.), but had been exposed to Pb from 3 mo-32 yr. They were divided into 2 groups, one showing slight Pb absorption with 100-300 mg/l porphyrin in urine, 100-300/million stippled erythrocytes (SE) (13 cases), and the other, higher Pb absorption group with >300 mg/l porphyrin in urine, >300 SE (12 cases). Mosatil was given orally (3 g/day for 10 days); Pb exposure was not changed. In the 1st group the number of SE was reduced in50% of the cases and porphyrin in urine diminished to values below normal in almost all cases. Considerably less improvement was observed in the 2nd group. SE dropped to numbers below normal in only 1 patient and porphyrinuria was reduced in only 30%.
On the basis of the results, it is concluded that the use of Mosatil is indicated in cases where Pb absorption is slight, without changing working conditions; however, where Pb absorption is of higher degree, it is indicated only with removal of the worker from exposure to Pb. It is also admonished that in the latter case improvements in working conditions are absolutely necessary.]

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