504.

Shibata S. Toxicological studies of EDTA salt (disodium ethylenediaminetetraacetate). Nippon Yakurigaku Zasshi. 1956; 52:113-119. (CA51:9918b) [Chronic toxicity of EDTA was studied. The L.D.50 of EDTA in the rabbit was 47 mg./kg. intravenously and 2.3 g./kg. orally. The death was preceded by slight convulsion. Intravenously the velocity of injection had great influence on the toxicity; injection of the L.D.50 doses in 10 min. killed none of the test animals. Oral administration of daily 1 g. EDTA/kg. rabbit for 7 days killed all of the test animals. Intravenous injection of daily 10 and 20 mg./kg. EDTA in 5% soln. and oral administration of daily 500 mg./kg. for 1 month killed none of the rabbits; in no case the body wt. decreased nor the urinary contents of protein and urobilinogen changed. The above administrations of EDTA in rabbits caused no change in the no. of leucocytes, no. of erythrocytes, amt. of blood pigment, and distribution of leucocytes. Intravenous injection of daily 10 and 20 mg./kg. or oral administration of 500 mg. and 1 g./kg. EDTA for 1 month in rabbits caused considerable cellular deformations in liver, kidney, endocrine organs, heart muscle, digestive tracts, and brain, while 1 mg./kg. intravenously or 100 mg/kg orally caused slight increase of reticular cells in lymphatic glands and suprarenal glands.]

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